Seminar: "Regulation of Autophagy by the Integrated Stress Response (ISR)" - Saad Farooq

Endocrinology and Animal Biosciences Seminar:

"Regulation of Autophagy by the Integrated Stress Response (ISR)"

Saad Farooq
Ph.D. Student
Graduate Program in Endocrinology and Animal Biosciences, Rutgers

The Integrated Stress Response (ISR) and autophagy are two pathways that regulate proteostasis and promote cellular adaptation to stress. Previous in-vitro studies have reported that ISR proteins, specifically ATF4 and CHOP, regulate autophagy during amino acid deprivation and endoplasmic reticulum (ER) stress, however, this relationship has not been confirmed in-vivo. This work contributes to addressing this research gap via an in-vivo investigation of ATF4 and CHOP’s role in regulating autophagy under the context of different cellular stressors.